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General Information
    • ISSN: 1793-8236 (Online)
    • Abbreviated Title Int. J. Eng. Technol.
    • Frequency:  Quarterly 
    • DOI: 10.7763/IJET
    • Managing Editor: Ms. Jennifer Zeng
    • Abstracting/ Indexing: Inspec (IET), CNKI Google Scholar, EBSCO, ProQuest, Crossref, etc.
    • E-mail: ijet_Editor@126.com
IJET 2023 Vol.15(4): 149-155
DOI: 10.7763/IJET.2023.V15.1238

Research on Ageing Based on D2030.4 by RNA Interference Impairs Lifespan in Caenorhabditis Elegans

Qinya Liu and Yang Li*

Abstract—Ageing has been a mystery to humanity for millennia. It has been a burden for numerous people, from the minority that suffer from progeria to the plethora of people who, due to ageing, are more susceptible to diseases such as Alzheimer’s disease and coronary artery disease. The aim of this study was to identify genes that regulate aging and elucidate their mechanisms. A Caenorhabditis elegans RNAi screen was performed to assess the role of these genes in the regulation of aging. For the first time, D2030.4 deficiency was found to accelerate senescence at 20 °C, comparable to DAF-16, a putative regulator of senescence. The results showed that D2030.4 deletion could down-regulate the expression level of GAS-1 mRNA and actively participate in the regulation of ROS in mitochondria. Therefore, D2030.4 may inhibit senescence by regulating ROS production. The Caenorhabditis elegans gene D2030.4 is conserved in many species, including humans, making it a potential target for anti-aging drugs.

Index Terms—Ageing, mitochondrial respiratory chain, caenorhabditis elegans

Qinya Liu is with King’s College Soto de Viñuelas in Madrid, Spain. Yang Li is with Zhejiang University in Zhejiang, China.
*Correspondence: 11618021@zju.edu.cn (Y.L.)


Cite: Qinya Liu and Yang Li, "Research on Ageing Based on D2030.4 by RNA Interference Impairs Lifespan in Caenorhabditis Elegans," International Journal of Engineering and Technology vol. 15, no. 4, pp. 149-155, 2023.

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