doi: 10.7763/IJET.2023.V15.1238
Research on Ageing Based on D2030.4 by RNA Interference Impairs Lifespan in Caenorhabditis Elegans
- 1 King’s College Soto de Viñuelas in Madrid, Spain
- 2 Zhejiang University in Zhejiang, China
Abstract
Ageing has been a mystery to humanity formillennia. It has been a burden for numerous people, from theminority that suffer from progeria to the plethora of people who,due to ageing, are more susceptible to diseases such asAlzheimer’s disease and coronary artery disease. The aim ofthis study was to identify genes that regulate aging andelucidate their mechanisms. A Caenorhabditis elegans RNAiscreen was performed to assess the role of these genes in theregulation of aging. For the first time, D2030.4 deficiency wasfound to accelerate senescence at 20 °C, comparable to DAF-16,a putative regulator of senescence. The results showed thatD2030.4 deletion could down-regulate the expression level ofGAS-1 mRNA and actively participate in the regulation of ROSin mitochondria. Therefore, D2030.4 may inhibit senescence byregulating ROS production. The Caenorhabditis elegans geneD2030.4 is conserved in many species, including humans,making it a potential target for anti-aging drugs.
Keywords
- Ageing
- mitochondrial respiratory chain
- caenorhabditis elegans
How to Cite
Qinya Liu and Yang Li, "Research on Ageing Based on D2030.4 by RNA Interference Impairs Lifespan in Caenorhabditis Elegans," International Journal of Engineering and Technology, vol. 15, no. 4, pp. 149-155, 2023. https://doi.org/ 10.7763/IJET.2023.V15.1238
Copyright & License
Copyright © 2023 by the authors. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).