doi: 10.7763/IJET.2009.V1.61
Cinnamomum Iners as Mitogen-Activated Protein Kinase Kinase (MKK1) Inhibitor
- School of Science and Technology, Universiti Malaysia Sabah
Abstract
Novel inhibitors targeting signal transductions have emerged for cancer therapies. Cinnamomum species have been reported to inhibit the proliferation of various cell lines. In this study, the methanol and acetone extracts of Cinnamomum iner’s leaves demonstrated significant anti-kinase activity against MKK1 in the signal transduction pathway at quantity as low as 1 and 6 mg respectively. Both of the extracts were found to contain polyphenol and flavonoid with potent anti-oxidation activity against DPPH free radicals (IC50=0.2 and 0.3 mg/mL respectively). In conclusion, the extracts may serve as potential MKK1 inhibitors which can be developed into anti-cancer drug.
Keywords
- Anti-cancer drug
- anti-kinases
- Cinnamomum iners
- MKK1
- signal transduction
How to Cite
Kam-Lee Pang, Wei-Li Thong, and Siew-Eng How, "Cinnamomum Iners as Mitogen-Activated Protein Kinase Kinase (MKK1) Inhibitor," International Journal of Engineering and Technology, vol. 1, no. 4, pp. 310-313, 2009. https://doi.org/ 10.7763/IJET.2009.V1.61
Copyright & License
Copyright © 2009 by the authors. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).